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FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

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$39.98

$ 18 .99 $18.99

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1.Size:6 Count


About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
  • Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus



4.4 out of 5 stars Date First Available September 2, 2004 Item Package Dimensions L x W x H 5.83 x 4.4 x 0.75 inches Item Dimensions LxWxH 5.75 x 0.75 x 4.5 inches Item Weight 18.14 g Brand Name Frontline Target Audience Keyword dogs, ( reptiles | amphibians ), dogs|( reptiles | amphibians ) Directions Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 45 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frequency Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days. Country of Origin France Warranty Description only for dog Model Name FRONTLINE Plus for Dogs Medium Dog (23-44 pounds) Flea and Tick Treatment, 3 Doses Color Purple Box Size 3 Count Material S-Methoprene, Fipronil Age Range Description All Life Stages Care Instructions Do not use on kittens under 8 weeks of age or 1.5 lbs Number of Items 1 Manufacturer Boehringer Ingelheim Animal Health Style Large Dog (45-88 lbs.) Breed Recommendation Large Dog, 45 to 88 pounds Included Components Package includes 3 applicators Specific Uses for Product Parasites

Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.


Heather Rae
Reviewed in the United States on March 8, 2025
I have been using Frontline Plus on my animals for years. Even when people were switching to the Frontline gold I stuck with plus. It kills fleas and ticks. I found it needs to be on them before flea and tick season by 1-2 months. Once its on them it works how it should. I think it is a safe effective way for the money.My pets and myself have issues with all the different chemicals and this one seems to work on all my animals without side effects.
Linda in Winlock
Reviewed in the United States on March 4, 2025
Easy to apply and it works.
Mary B.
Reviewed in the United States on February 27, 2025
I've been using Frontline Plus for years for my dogs, and it works as described. If a tick does get on my dog, it dies before it can transmit Lymes. Never had a flea, etc., while using Frontline. I also feel it is less toxic than some of the other products.
Angel young
Reviewed in the United States on February 26, 2025
Works Good
Kimberly Zittlow
Reviewed in the United States on November 22, 2024
Frontline Plus is my go-to flea and tick solution for my large dog! I have a big Blue Heeler who loves spending time outdoors, rolling in the grass, and exploring wooded trails. This product has been a total game changer for keeping him pest-free and happy.Applying it is super simple. The applicator is well-designed to make sure the liquid goes directly onto the skin, and it dries quickly, so there’s no mess or greasy residue. I love that I don’t have to worry about fleas or ticks for a full month—it’s long-lasting and incredibly effective.Since using Frontline Plus, I’ve noticed a huge improvement. No more scratching or irritability, and I haven’t spotted a single flea or tick on him, even after long hikes. It gives me peace of mind knowing he’s protected, especially since ticks can carry dangerous diseases.Another big plus is that this product works without causing any side effects. My Heeler has sensitive skin, and I’ve never had issues with irritation or reactions. It’s clear that Frontline takes pet safety seriously.If you have a large, active dog like mine, this is a must-have for keeping pests at bay. It’s worth every penny for the protection and comfort it provides. Highly recommend!
Douglas fernandes
Reviewed in India on September 5, 2017
It was very helpful I managed to get control of the continue scratching on her back
Sen-Sen
Reviewed in India on September 29, 2017
It works
Peter Suslock
Reviewed in the United States on August 18, 2012
Allow me to caveat this review by saying out of 700 plus reviews this is the most difficult to write as I despise having to use pesticides on our dogs. That said, we live in Tick and Flea central, surrounded by deep woods and our bulldogs are in every sense of the word family and we do whatever we must to protect them. That said if you're reading these reviews your dog or dogs are your heart too and using these products is a difficult choice to make, but it's one we have to make.On that note, it's my hope the following information has some value for you.Frontline was first put into clinical trials in 1985 shortly after the discovery of it's active ingredient Fipronil. To it's credit Frontline has maintained the safest albeit not the most effective treatment for fleas and ticks. However, the more effective products pose a significantly greater risk to your dog.It's a slippery slope, but in evaluating what's best for your dog by providing the highest level protection with the lowest risk Frontline and FrontLine Plus are in my opinion your best bet.Most tick and flea products contain Permethrin which may also be listed as Lyclear or Nix as the active ingredient. Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it can do dire damage. Thousands of dogs die every year from Permethrin. Although the FDA has mandated a minimal use not to exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price.What makes Permethrin so dangerous is that it can't distinguish between insects and mammals which of course includes human beings. It's been known to be lethal to cats since the 1970's. In fact it's so deadly to cats that even a slight transfer from dog to cat can result in seizures, brain damage and death. Permethrin is volatile as well - meaning it's airborne properties pose a threat to all who breath it in - humans included.Frontline on the other hand uses Fipronil. Fipronil is an insecticide.Like any chemical of this nature it can be lethal at too high of a dose. However studies including those from the Department of Environmental Conservation have determined time and time again that as long as the amount of Fipronil is at the correct dose for the weight and size of your dog toxicity is far easier to avoid and the product much safer for your dog. Unlike Premethrin, Fipronil is absorbed into the hair follicles and oil glands only. It is not absorbed into the dogs system nor is it volatile so you and your beloved pets and children can breath easy. The second active ingredient in FrontLine Plus is Methoprene which is a long existing and time proven IGR (insect growth regulator) it's distributed exactly like Fipronil but only acts on flea and tick eggs and Larvae - this is important because it kills these vermin at the start of a new life cycle. What is more, the diseases that ticks carry now are infinitely more serious than the dreaded Lime disease - which for decades was the only concern.Competitors to Frontline (and some Vets selling other products) claim that fleas and ticks have become resistant to Frontline - However these pests have become resistant to some degree to all pesticides and no independent research exists to confirm this claim. I can assure you I've researched this in the greatest depth.The bottom line is this - all of these products pose a risk.The wise choice is to minimize that risk in your effort to protect your best friend from the diseases these vermin carry. Again, these diseases can be infinitely more lethal than the ingredients of the protection. To that end your safest and most effective choice is Frontline or Frontline Plus.In the event your pet has a bad reaction to Frontline products these are the symptoms you would see:* Restlessness* Itching* Vomiting* Difficulty Breathing* LethargyShould these symptoms occur, of course take your pet to your Veterinarian or emergency clinic immediately. It should be a comfort to know that unlike the toxic ingredients in most other flea and tick control products severe reactions to both Fipronil and Methoprene are rare.